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This website is intended for patients who have been prescribed Evenity®▼ (romosozumab) and have signed up to the support programme.
Information placed on this digital platform is not intended as a substitute for consultation with your doctor.

Instructions For Use

Refer to the Patient Information Leaflet 'Instructions for Use' section that came with your Evenity medication or visit www.medicines.org.uk.

It is important to make sure that the injection is only administered by an individual that has been properly trained. Below are helpful reminders for the person administering the medication:

  • Your pre-filled pens should be left outside the refrigerator to reach room temperature (up to 25°C) for at least 30 minutes before injection (do not warm in any other way). This will make the injection more comfortable. You can keep the pre-filled pens at room temperature (up to 25°C) for up to 30 days. If not used within this period the product should be discarded. Do not freeze
  • Pull the white cap straight off just right before the injection (do not twist or bend the white cap)
  • Clean the chosen injection site with an alcohol swab
  • DO NOT push down on the pre-filled pen until you’re ready to inject
  • When the injection is complete, the viewing window will turn fully yellow and you may also hear or feel a second click (which may take up to 15 seconds)
  • Once the pre-filled pen is removed from the skin, the needle will be automatically covered
  • If the viewing window has not turned fully yellow, or if it looks as though the medicine is still injecting, it means you have not received a full dose. Call your healthcare provider immediately
    • Repeat all steps from the ‘Instructions for Use’ Leaflet for the second injection
    • The second injection should not be administered at the exact same location used for the first injection

INSTRUCTIONS FOR USE FOR THE Evenity INJECTION BY MEANS OF PRE-FILLED PENS
Inject two pre-filled pens, one immediately after the other to get a full dose

The following instructions explain how to use the pre-filled pens to inject Evenity.

  • Please read the instructions carefully and follow them step-by-step
  • If you have any questions or you feel unsure about the injection procedure, please contact a doctor or pharmacist
  • It is important to make sure that the injection is only administered by an individual that has been properly trained
  • The pre-filled pens are also referred to as “the medicine”

stop icon

Read this before the medicine is injected.

Your healthcare provider has prescribed a dose of 210 mg every month: To receive your full dose, two 105 mg pre-filled pens should be injected, one immediately after the other.

step visual

 

Step 1: Prepare
A
  • Take the carton containing the two pre-filled pens out of the refrigerator
  • Your pre-filled pens should be left outside the refrigerator to reach room temperature (up to 25°C) for at least 30 minutes before injection (do not warm in any other way). This will make the injection more comfortable
  • Open the carton and gather all materials you need for the injection (as listed in Step B)
  • Wash your hands thoroughly
  • Lift the pre-filled pens straight up out of the carton - do not remove the white caps from the pre-filled pen yet
  • Do not shake the pre-filled pens
  • Check the medicine through the viewing window. The medicine should be a clear to opalescent, 
    colourless to light yellow solution
    - Do not use the pre-filled pens if the solution is discoloured, cloudy, or contains flakes or particles
    - You may see air bubbles. Injecting the solution subcutaneously (under the skin) which contains air bubbles is harmless
  • Do not use the pre-filled pens if:
    - it has been dropped
    - the white cap is missing or not securely attached
    - the seal is missing or broken or if any other part appears cracked or broken
    In such cases, use a new pen and contact your doctor as soon as possible
B
On a clean, well-lit work surface, place:
  • two pre-filled pens
  • two alcohol wipes
  • two cotton balls or gauze pads
  • two adhesives bandages
  • special disposal container
b visual
C

Prepare and clean the place you are going to inject. You can choose from:

  • the thighs
  • the stomach area (abdomen), but not the 5 cm area around the belly button
  • the outer area of the upper arm (if someone else is giving you the injection)

 

C
  • The second injection should be given on a different site than the one used for the first injection. If you wish to use the same injection site, make sure it is not the exact same injection spot
  • Do not inject into areas where the skin is tender, bruised, red, hard, has scars, or stretch marks, or has raised thick, red, or scaly skin patches or lesions
  • Clean the area you are going to inject with an alcohol wipe. Let the skin dry before the injection

 

clean the area
  • Do not touch this area again before injecting
Step 2: Get ready
D
  • Pull the white cap straight off just before the injection
  • Once the cap is removed, the injection must be given within 5 minutes. There is no need to rush the injection
    - 5 minutes is enough time
D
  • Do not twist or bend the white cap
  • Discard the white cap in the special disposal container. Do not place the white cap back onto the pre-filled pen
  • Although hidden from view, the needle tip is now uncovered. Do not try to touch the needle as it could activate the pre-filled pen. It is normal to see a drop of liquid at the end of the needle (inside the yellow safety guard)
E

Stretch or pinch the injection site to create a firm surface.

Stretch method

  • Stretch the skin firmly by moving thumb and fingers in opposite directions, to create an area about 5 cm wide

 

stretch skin

 

OR

Pinch method

  • Pinch the skin firmly between thumb and fingers, to create an area about 5 cm wide
  • Important: Keep the skin stretched or pinched while injecting

 

E

 

Step 3: Inject
F
  • Important: The pre-filled pen should not be pushed down until the actual injection is ready to be performed
  • The stretch or pinch should be held. With the other hand, the pre-filled pen's yellow safety guard should be placed down on the area of the skin that previously has been cleaned (the “injection site”) at a 90° angle
F

 

G
  • The pre-filled pen should be firmly pushed down onto the skin until the yellow safety guard stops moving. When you hear or feel a click, the injection will begin
H
  • Keep pushing down on the skin. The injection could take about 15 seconds
  • When the injection is complete, the viewing window will turn fully yellow and you may also hear or feel a second click
G

 

H

 

  • The used pre-filled pen may now be removed by carefully pulling it straight up from the skin
  • Important: When you remove the pre-filled pen, if the window has not turned fully yellow, or if it looks like the medicine is still injecting, this means the full dose has not been delivered. The healthcare provider should be informed as soon as possible
  • After removing the pre-filled pens from the skin, the needle will be automatically covered. Do not try to touch the needle
Step 4: Dispose
I
  • Discard the entire used pre-filled pen and the white cap in a special container straight away after use

 

I
  • Do not throw away (dispose of) the pre-filled pen in the household waste
  • Do not re-use the pre-filled pen
  • Important: Always keep the special disposal container out of the sight and reach of children
Step 5: Examine the injection site
J

If there is blood, use a cotton ball or a piece of gauze and apply light pressure over the injection site for a few seconds. Do not rub the injection site. The injection site can be covered with a small adhesive bandage, if necessary.

Step 6: Repeat for the second injection to get the full dose
K

Repeat all steps starting from step C with the second pre-filled pen to inject the full dose. The second injection should be given on a different site than the one used for the first injection. If you wish to use the same injection site, make sure it is not the exact same injection spot.

 

dose